Altering O-Linked β-N-Acetylglucosamine Cycling Disrupts Mitochondrial Function

Mitochondrial impairment is commonly found in many diseases such as diabetes, cancer, and Alzheimer disease. We demonstrate that the enzymes responsible for the addition or removal of the O-GlcNAc modification, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), respectively, are critical regulators o...

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Detalhes bibliográficos
Main Authors: Tan, Ee Phie, Villar, Maria T., E, Lezi, Lu, Jianghua, Selfridge, J. Eva, Artigues, Antonio, Swerdlow, Russell H., Slawson, Chad
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031527/
https://ncbi.nlm.nih.gov/pubmed/24713701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.525790
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