Hepatic Scavenger Receptor BI Protects Against Polymicrobial-induced Sepsis through Promoting LPS Clearance in Mice

Recent studies revealed that scavenger receptor BI (SR-BI or Scarb1) plays a critical protective role in sepsis. However, the mechanisms underlying this protection remain largely unknown. In this study, using Scarb1(I179N) mice, a mouse model specifically deficient in hepatic SR-BI, we report that h...

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Bibliographische Detailangaben
Hauptverfasser: Guo, Ling, Zheng, Zhong, Ai, Junting, Huang, Bin, Li, Xiang-An
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031522/
https://ncbi.nlm.nih.gov/pubmed/24719333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.537258
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