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Resistance to Raf inhibition in cancer

The use of small molecule BRAF inhibitors has revolutionized the treatment of advanced melanoma. Despite this, resistance is commonplace and associated with a median progression-free survival of >5 months. Major resistance mechanisms include reactivation of the MAPK pathway and increased PI3K/AKT...

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Autori principali: Haarberg, H. Eirik, Smalley, Keiran S.M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031441/
https://ncbi.nlm.nih.gov/pubmed/24847650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ddtec.2013.12.004
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