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Resistance to Raf inhibition in cancer
The use of small molecule BRAF inhibitors has revolutionized the treatment of advanced melanoma. Despite this, resistance is commonplace and associated with a median progression-free survival of >5 months. Major resistance mechanisms include reactivation of the MAPK pathway and increased PI3K/AKT...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4031441/ https://ncbi.nlm.nih.gov/pubmed/24847650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ddtec.2013.12.004 |
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