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Inhibition of Wee1, AKT and CDK4 underlies the efficacy of the HSP90 inhibitor XL888 in an in vivo model of NRAS mutant melanoma

The HSP90 inhibitor XL888 is effective at reversing BRAF inhibitor resistance in melanoma, including that mediated through acquired NRAS mutations. The present study has investigated the mechanism of action of XL888 in NRAS mutant melanoma. Treatment of NRAS mutant melanoma cell lines with XL888 led...

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Библиографические подробности
Главные авторы: Haarberg, H. Eirik, Paraiso, Kim H. T., Wood, Elizabeth, Rebecca, Vito W., Sondak, Vernon K., Koomen, John M., Smalley, Keiran S. M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683468/
https://ncbi.nlm.nih.gov/pubmed/23538902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-1003
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