High-Content, High-Throughput Analysis of Cell Cycle Perturbations Induced by the HSP90 Inhibitor XL888

BACKGROUND: Many proteins that are dysregulated or mutated in cancer cells rely on the molecular chaperone HSP90 for their proper folding and activity, which has led to considerable interest in HSP90 as a cancer drug target. The diverse array of HSP90 client proteins encompasses oncogenic drivers, c...

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Main Authors: Lyman, Susan K., Crawley, Suzanne C., Gong, Ruoyu, Adamkewicz, Joanne I., McGrath, Garth, Chew, Jason Y., Choi, Jennifer, Holst, Charles R., Goon, Leanne H., Detmer, Scott A., Vaclavikova, Jana, Gerritsen, Mary E., Blake, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049797/
https://ncbi.nlm.nih.gov/pubmed/21408192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017692
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