Pre-Clinical Characterization of Dacomitinib (PF-00299804), an Irreversible Pan-ErbB Inhibitor, Combined with Ionizing Radiation for Head and Neck Squamous Cell Carcinoma

Epidermal growth factor receptor (EGFR) is over-expressed in nearly all cases of squamous cell carcinoma of the head and neck (SCCHN), and is an important driver of disease progression. EGFR targeted therapies have demonstrated clinical benefit for SCCHN treatment. In this report, we investigated th...

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Main Authors: Williams, Justin P., Kim, Inki, Ito, Emma, Shi, Wei, Yue, Shijun, Siu, Lillian L., Waldron, John, O'Sullivan, Brian, Yip, Kenneth W., Liu, Fei-Fei
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031184/
https://ncbi.nlm.nih.gov/pubmed/24853121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098557
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