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Effect of Small Molecule Binding Affinity on Tumor Uptake In Vivo: A Systematic Study Using a Pretargeted Bispecific Antibody

Small molecule ligands specific for tumor-associated surface receptors have wide applications in cancer diagnosis and therapy. Achieving high-affinity binding to the desired target is important for improving detection limits and for increasing therapeutic efficacy. However, the affinity required for...

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Bibliografski detalji
Glavni autori: Orcutt, Kelly Davis, Rhoden, John J, Ruiz-Yi, Benjamin, Frangioni, John V, Wittrup, K Dane
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030749/
https://ncbi.nlm.nih.gov/pubmed/22491799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-11-0764
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