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The role of metal binding and phosphorylation domains in the regulation of cisplatin-induced trafficking of ATP7B
The copper (Cu) exporter ATP7B mediates cellular resistance to cisplatin (cDDP) by increasing drug efflux. ATP7B binds and sequesters cDDP in into secretory vesicles. Upon cDDP exposure ATP7B traffics from the trans-Golgi network (TGN) to the periphery of the cell in a manner that requires the cyste...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4030745/ https://ncbi.nlm.nih.gov/pubmed/23803742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3mt00131h |
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