Modulation of de novo purine biosynthesis leads to activation of AMPK and results in improved glucose handling and insulin sensitivity

BACKGROUND: AMP activated protein kinase (AMPK) regulates key metabolic reactions and plays a major role in glucose homeostasis. Activating the AMPK is considered as one of the potential therapeutic strategies in treating type-2 diabetes. However, targeting AMPK by small molecule mediated approach c...

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Hoofdauteurs: Sadasivan, Satish Kumar, Vasamsetti, Balamuralikrishna, Singh, Jaideep, Siddaraju, Nethra, Khan, Khaiser Mehdi, Oommen, Anup Mammen, Jagannath, Madanalli R, Rao, Raghavendra Pralhada
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2014
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030739/
https://ncbi.nlm.nih.gov/pubmed/24855629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2251-6581-13-51
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