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Redesigning enzymes based on adaptive evolution for optimal function in synthetic metabolic pathways
Nature has balanced most metabolic pathways such that no one enzyme in the pathway controls the flux through that pathway. However, unnatural or non-native, constructed metabolic pathways may have limited product flux due to unfavorable in vivo properties of one or more enzymes in the pathway. One s...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4030648/ https://ncbi.nlm.nih.gov/pubmed/18559271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.05.006 |
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