Enhanced Stability and Knockdown Efficiency of Poly(ethylene glycol)- polyphosphoramidate/siRNA Micellar Nanoparticles by Co-condensation with Sodium Triphosphate

PURPOSE: Polyelectrolyte complex nanoparticles are a promis ing vehicle for siRNA delivery but suffer from low stability under physiological conditions. An effective stabilization meth od is essential for the success of polycationic nanoparticle mediated siRNA delivery. In this study, sodium triphos...

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Autori principali: Nakanishi, Masataka, Patil, Rajesh, Ren, Yong, Shyam, Rishab, Wong, Philip, Mao, Hai Quan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030395/
https://ncbi.nlm.nih.gov/pubmed/21387148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-011-0408-7
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