Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity

Patients with established type 2 diabetes display both β-cell dysfunction and insulin resistance. To define fundamental processes leading to the diabetic state, we examined the relationship between type 2 diabetes risk variants at 37 established susceptibility loci, and indices of proinsulin process...

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Main Authors: Dimas, Antigone S., Lagou, Vasiliki, Barker, Adam, Knowles, Joshua W., Mägi, Reedik, Hivert, Marie-France, Benazzo, Andrea, Rybin, Denis, Jackson, Anne U., Stringham, Heather M., Song, Ci, Fischer-Rosinsky, Antje, Boesgaard, Trine Welløv, Grarup, Niels, Abbasi, Fahim A., Assimes, Themistocles L., Hao, Ke, Yang, Xia, Lecoeur, Cécile, Barroso, Inês, Bonnycastle, Lori L., Böttcher, Yvonne, Bumpstead, Suzannah, Chines, Peter S., Erdos, Michael R., Graessler, Jurgen, Kovacs, Peter, Morken, Mario A., Narisu, Narisu, Payne, Felicity, Stancakova, Alena, Swift, Amy J., Tönjes, Anke, Bornstein, Stefan R., Cauchi, Stéphane, Froguel, Philippe, Meyre, David, Schwarz, Peter E.H., Häring, Hans-Ulrich, Smith, Ulf, Boehnke, Michael, Bergman, Richard N., Collins, Francis S., Mohlke, Karen L., Tuomilehto, Jaakko, Quertemous, Thomas, Lind, Lars, Hansen, Torben, Pedersen, Oluf, Walker, Mark, Pfeiffer, Andreas F.H., Spranger, Joachim, Stumvoll, Michael, Meigs, James B., Wareham, Nicholas J., Kuusisto, Johanna, Laakso, Markku, Langenberg, Claudia, Dupuis, Josée, Watanabe, Richard M., Florez, Jose C., Ingelsson, Erik, McCarthy, Mark I., Prokopenko, Inga
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Diabetes Association 2014
Ábhair:
Genetics/Genomes/Proteomics/Metabolomics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030103/
https://ncbi.nlm.nih.gov/pubmed/24296717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0949
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