Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1

BACKGROUND: Doublecortin-like kinase 1 (DCLK1) is emerging as a tumor specific stem cell marker in colorectal and pancreatic cancer. Previous in vitro and in vivo studies have demonstrated the therapeutic effects of inhibiting DCLK1 with small interfering RNA (siRNA) as well as genetically targeting...

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Main Authors: Weygant, Nathaniel, Qu, Dongfeng, Berry, William L, May, Randal, Chandrakesan, Parthasarathy, Owen, Daniel B, Sureban, Sripathi M, Ali, Naushad, Janknecht, Ralf, Houchen, Courtney W
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2014
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030036/
https://ncbi.nlm.nih.gov/pubmed/24885928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-103
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