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Cytoplasmic Localization of p21 Protects Trophoblast Giant Cells from DNA Damage Induced Apoptosis

Proliferating trophoblast stem cells (TSCs) can differentiate into nonproliferating but viable trophoblast giant cells (TGCs) that are resistant to DNA damage induced apoptosis. Differentiation is associated with selective up-regulation of the Cip/Kip cyclin-dependent kinase inhibitors p57 and p21;...

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Détails bibliographiques
Auteurs principaux: de Renty, Christelle, DePamphilis, Melvin L., Ullah, Zakir
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029599/
https://ncbi.nlm.nih.gov/pubmed/24848107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097434
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