Intrathecal leptin inhibits expression of the P2X(2/3) receptors and alleviates neuropathic pain induced by chronic constriction sciatic nerve injury

BACKGROUND: Leptin, an adipocytokine produced mainly by white adipose tissue, has a broad role in the regulation of neuronal functions. Accumulating evidence has revealed that leptin plays an important role in influencing neuropathic pain, shown recently by the finding that chronic administration of...

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Main Authors: Li, Xin, Kang, Lumei, Li, Guilin, Zeng, Huihong, Zhang, Lei, Ling, Xiang, Dong, Hui, Liang, Shangdong, Chen, Hongping
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2013
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029482/
https://ncbi.nlm.nih.gov/pubmed/24325936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-9-65
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