A Conceptual Framework for Pharmacodynamic Genome-wide Association Studies in Pharmacogenomics

Genome-wide association studies (GWAS) have emerged as a powerful tool to identify loci that affect drug response or susceptibility to adverse drug reactions. However, current GWAS based on a simple analysis of associations between genotype and phenotype ignores the biochemical reactions of drug res...

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Autori principali: Wu, Rongling, Tong, Chunfa, Wang, Zhong, Mauger, David, Tantisira, Kelan, Szefler, Stanley J., Chinchilli, Vernon M., Israel, Elliot
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029408/
https://ncbi.nlm.nih.gov/pubmed/21920452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2011.09.001
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