BIM(EL) is a key effector molecule in oxidative stress-mediated apoptosis in acute myeloid leukemia cells when combined with arsenic trioxide and buthionine sulfoximine

ABSTRACTS: BACKGROUND: Arsenic trioxide (ATO) is reported to be an effective therapeutic agent in acute promyelocytic leukemia (APL) through inducing apoptotic cell death. Buthionine sulfoximine (BSO), an oxidative stress pathway modulator, is suggested as a potential combination therapy for ATO-ins...

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Hauptverfasser: Tanaka, Yukie, Komatsu, Takayuki, Shigemi, Hiroko, Yamauchi, Takahiro, Fujii, Yutaka
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029189/
https://ncbi.nlm.nih.gov/pubmed/24428916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-27
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