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Characterization of an environmental DNA derived gene cluster that encodes for the bisindolylmaleimide methylarcyriarubin

Bisindolylmaleimides represent a naturally occurring class of metabolites that are of interest because of their protein kinase inhibition activity. From a metagenomic library constructed using soil DNA, we identified the four gene mar cluster, a bisindolylmaleimide gene cluster that encodes for meth...

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Bibliographic Details
Main Authors: Chang, Fang-Yuan, Brady, Sean F.
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028703/
https://ncbi.nlm.nih.gov/pubmed/24648189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201300756
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