Loss of MAP Function Leads to Hippocampal Synapse Loss and Deficits in the Morris Water Maze with Aging

Hyperphosphorylation and accumulation of tau aggregates are prominent features in tauopathies, including Alzheimer's disease, but the impact of loss of tau function on synaptic and cognitive deficits remains poorly understood. We report that old (19–20 months; OKO) but not middle-aged (8–9 mont...

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Detalhes bibliográficos
Main Authors: Ma, Qiu-Lan, Zuo, Xiaohong, Yang, Fusheng, Ubeda, Oliver J., Gant, Dana J., Alaverdyan, Mher, Kiosea, Nicolae C., Nazari, Sean, Chen, Ping Ping, Nothias, Fatiha, Chan, Piu, Teng, Edmond, Frautschy, Sally A., Cole, Greg M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028492/
https://ncbi.nlm.nih.gov/pubmed/24849348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3439-13.2014
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