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Analysis of a lung defect in autophagy-deficient mouse strains
Yeast Atg1 initiates autophagy in response to nutrient limitation. The Ulk gene family encompasses the mammalian orthologs of yeast ATG1. We created mice deficient for both Ulk1 and Ulk2 and found that the mice die within 24 h of birth. When found alive, pups exhibited signs of respiratory distress....
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Landes Bioscience
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4028323/ https://ncbi.nlm.nih.gov/pubmed/24275123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.26505 |
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