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Analysis of a lung defect in autophagy-deficient mouse strains

Yeast Atg1 initiates autophagy in response to nutrient limitation. The Ulk gene family encompasses the mammalian orthologs of yeast ATG1. We created mice deficient for both Ulk1 and Ulk2 and found that the mice die within 24 h of birth. When found alive, pups exhibited signs of respiratory distress....

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Detalhes bibliográficos
Main Authors: Cheong, Heesun, Wu, Junmin, Gonzales, Linda K, Guttentag, Susan H, Thompson, Craig B, Lindsten, Tullia
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028323/
https://ncbi.nlm.nih.gov/pubmed/24275123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.26505
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