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Analysis of a lung defect in autophagy-deficient mouse strains

Yeast Atg1 initiates autophagy in response to nutrient limitation. The Ulk gene family encompasses the mammalian orthologs of yeast ATG1. We created mice deficient for both Ulk1 and Ulk2 and found that the mice die within 24 h of birth. When found alive, pups exhibited signs of respiratory distress....

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Bibliografski detalji
Glavni autori: Cheong, Heesun, Wu, Junmin, Gonzales, Linda K, Guttentag, Susan H, Thompson, Craig B, Lindsten, Tullia
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028323/
https://ncbi.nlm.nih.gov/pubmed/24275123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.26505
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