Analysis of a lung defect in autophagy-deficient mouse strains

Yeast Atg1 initiates autophagy in response to nutrient limitation. The Ulk gene family encompasses the mammalian orthologs of yeast ATG1. We created mice deficient for both Ulk1 and Ulk2 and found that the mice die within 24 h of birth. When found alive, pups exhibited signs of respiratory distress....

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Autori principali: Cheong, Heesun, Wu, Junmin, Gonzales, Linda K, Guttentag, Susan H, Thompson, Craig B, Lindsten, Tullia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2014
Soggetti:
Basic Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028323/
https://ncbi.nlm.nih.gov/pubmed/24275123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.26505
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