Mice Deficient in Transmembrane Prostatic Acid Phosphatase Display Increased GABAergic Transmission and Neurological Alterations

Prostatic acid phosphatase (PAP), the first diagnostic marker and present therapeutic target for prostate cancer, modulates nociception at the dorsal root ganglia (DRG), but its function in the central nervous system has remained unknown. We studied expression and function of TMPAP (the transmembran...

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Hauptverfasser: Nousiainen, Heidi O., Quintero, Ileana B., Myöhänen, Timo T., Voikar, Vootele, Mijatovic, Jelena, Segerstråle, Mikael, Herrala, Annakaisa M., Kulesskaya, Natalia, Pulkka, Anitta E., Kivinummi, Tanja, Abo-Ramadan, Usama, Taira, Tomi, Piepponen, T. Petteri, Rauvala, Heikki, Vihko, Pirkko
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028278/
https://ncbi.nlm.nih.gov/pubmed/24846136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097851
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