Immunization of Rabbits with Highly Purified, Soluble, Trimeric Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Induces a Vigorous B Cell Response and Broadly Cross-Reactive Neutralization

Previously we described induction of cross-reactive HIV-1 neutralizing antibody responses in rabbits using a soluble HIV-1 gp140 envelope glycoprotein (Env) in an adjuvant containing monophosphoryl lipid A (MPL) and QS21 (AS02(A)). Here, we compared different forms of the same HIV-1 strain R2 Env fo...

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Autores principales: Quinnan, Gerald V., Onabajo, Olusegun, Zhang, Pengfei, Yan, Lianying, Mattapallil, Joseph J., Zhang, Zhiqiang, Dong, Ming, Lu, Min, Montefiori, David, LaBranche, Celia, Broder, Christopher C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028264/
https://ncbi.nlm.nih.gov/pubmed/24846288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098060
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