Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription

Parkinson’s disease (PD) is characterized by loss of A9 dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). An association has been reported between PD and exposure to mitochondrial toxins, including environmental pesticides paraquat, maneb, and rotenone. Here, using a robust, pa...

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Main Authors: Ryan, Scott D., Dolatabadi, Nima, Chan, Shing Fai, Zhang, Xiaofei, Akhtar, Mohd Waseem, Parker, James, Soldner, Frank, Sunico, Carmen R., Nagar, Saumya, Talantova, Maria, Lee, Brian, Lopez, Kevin, Nutter, Anthony, Shan, Bing, Molokanova, Elena, Zhang, Yaoyang, Han, Xuemei, Nakamura, Tomohiro, Masliah, Eliezer, Yates, John R., Nakanishi, Nobuki, Andreyev, Aleksander Y., Okamoto, Shu-ichi, Jaenisch, Rudolf, Ambasudhan, Rajesh, Lipton, Stuart A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028128/
https://ncbi.nlm.nih.gov/pubmed/24290359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.11.009
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