Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription

Parkinson’s disease (PD) is characterized by loss of A9 dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). An association has been reported between PD and exposure to mitochondrial toxins, including environmental pesticides paraquat, maneb, and rotenone. Here, using a robust, pa...

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Autori principali: Ryan, Scott D., Dolatabadi, Nima, Chan, Shing Fai, Zhang, Xiaofei, Akhtar, Mohd Waseem, Parker, James, Soldner, Frank, Sunico, Carmen R., Nagar, Saumya, Talantova, Maria, Lee, Brian, Lopez, Kevin, Nutter, Anthony, Shan, Bing, Molokanova, Elena, Zhang, Yaoyang, Han, Xuemei, Nakamura, Tomohiro, Masliah, Eliezer, Yates, John R., Nakanishi, Nobuki, Andreyev, Aleksander Y., Okamoto, Shu-ichi, Jaenisch, Rudolf, Ambasudhan, Rajesh, Lipton, Stuart A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028128/
https://ncbi.nlm.nih.gov/pubmed/24290359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.11.009
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