Role of sulfiredoxin as a peroxiredoxin-2 denitrosylase in human iPSC-derived dopaminergic neurons

Recent studies have pointed to protein S-nitrosylation as a critical regulator of cellular redox homeostasis. For example, S-nitrosylation of peroxiredoxin-2 (Prx2), a peroxidase widely expressed in mammalian neurons, inhibits both enzymatic activity and protective function against oxidative stress....

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Sunico, Carmen R., Sultan, Abdullah, Nakamura, Tomohiro, Dolatabadi, Nima, Parker, James, Shan, Bing, Han, Xuemei, Yates, John R., Masliah, Eliezer, Ambasudhan, Rajesh, Nakanishi, Nobuki, Lipton, Stuart A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127299/
https://ncbi.nlm.nih.gov/pubmed/27821734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608784113
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