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Creating Transgenic shRNA Mice by Recombinase-Mediated Cassette Exchange

RNA interference (RNAi) enables sequence-specific, experimentally induced silencing of virtually any gene by tapping into innate regulatory mechanisms that are conserved among most eukaryotes. The principles that enable transgenic RNAi in cell lines can also be used to create transgenic animals, whi...

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Bibliografische gegevens
Hoofdauteurs: Premsrirut, Prem K., Dow, Lukas E., Park, Youngkyu, Hannon, Gregory J., Lowe, Scott W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028064/
https://ncbi.nlm.nih.gov/pubmed/24003198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/pdb.prot077057
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