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Intraarterial Mitoxantrone Delivery in Rabbits: An Optical Pharmacokinetic Study

BACKGROUND: Several human studies have demonstrated the feasibility of intraarterial delivery of mitoxantrone in systemic malignancies. Computational models predict that intraarterial bolus injection of mitoxatrone during transient cerebral hypoperfusion will enhance brain tissue drug deposition com...

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Main Authors: Joshi, Shailendra, Reif, Roberto, Wang, Mei, Zhang, Jane, Ergin, Aysegul, Bruce, Jeffery N., Fine, Robert L., Bigio, Irving J.
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028021/
https://ncbi.nlm.nih.gov/pubmed/21430588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1227/NEU.0b013e3182181b67
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