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Noninvasive in vivo optical assessment of blood brain barrier permeability and brain tissue drug deposition in rabbits
Osmotic disruption of the blood brain barrier (BBB) by intraarterial mannitol injection is sometimes the key step for the delivery of chemotherapeutic drugs to brain tissue. BBB disruption (BBBD) with mannitol, however, can be highly variable and could impact local drug deposition. We use optical ph...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Society of Photo-Optical Instrumentation Engineers
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3381026/ https://ncbi.nlm.nih.gov/pubmed/22612147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1117/1.JBO.17.5.057008 |
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