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Noninvasive in vivo optical assessment of blood brain barrier permeability and brain tissue drug deposition in rabbits

Osmotic disruption of the blood brain barrier (BBB) by intraarterial mannitol injection is sometimes the key step for the delivery of chemotherapeutic drugs to brain tissue. BBB disruption (BBBD) with mannitol, however, can be highly variable and could impact local drug deposition. We use optical ph...

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Hlavní autoři: Ergin, Aysegul, Wang, Mei, Zhang, Jane, Bigio, Irving, Joshi, Shailendra
Médium: Artigo
Jazyk:Inglês
Vydáno: Society of Photo-Optical Instrumentation Engineers 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381026/
https://ncbi.nlm.nih.gov/pubmed/22612147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1117/1.JBO.17.5.057008
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