Results of a Randomized Phase I Gene Therapy Clinical Trial of Nononcolytic Fowlpox Viruses Encoding T Cell Costimulatory Molecules

Oncolytic viruses have shown promise as gene delivery vehicles in the treatment of cancer; however, their efficacy may be inhibited by the induction of anti-viral antibody titers. Fowlpox virus is a nonreplicating and nononcolytic vector that has been associated with lesser humoral but greater cell-...

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Autors principals: Kaufman, Howard L., Kim, Dae Won, Kim-Schulze, Seunghee, DeRaffele, Gail, Jagoda, Michael C., Broucek, Joseph R., Zloza, Andrew
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2014
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027985/
https://ncbi.nlm.nih.gov/pubmed/24484178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2013.217
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