Facile Synthesis and Preliminary Structure–Activity Analysis of New Sulfonamides Against Trypanosoma brucei

[Image: see text] The high throughput screening of a library of over 87,000 drug-like compounds against the African sleeping sickness parasite resulted in the discovery of hits with a wide range of molecular diversity. We report here the medicinal chemistry development of one such hit, a tetrahydroi...

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Autors principals: Rashad, Adel A., Jones, Amy J., Avery, Vicky M., Baell, Jonathan, Keller, Paul A.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027789/
https://ncbi.nlm.nih.gov/pubmed/24900868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400487t
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