Novel Delta Opioid Receptor Agonists with Oxazatricyclodecane Structure

[Image: see text] We synthesized compounds 4a,c–f,h,i containing the oxazatricyclodecane structure from a novel rearrangement reaction product 2a. All the prepared compounds 4a,c–f,h,i exhibited full agonistic activities for the δ opioid receptor (DOR). Among them, the N-methyl derivative 4c was hig...

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Autori principali: Fujii, Hideaki, Hayashida, Kohei, Saitoh, Akiyoshi, Yokoyama, Akinobu, Hirayama, Shigeto, Iwai, Takashi, Nakata, Eriko, Nemoto, Toru, Sudo, Yuka, Uezono, Yasuhito, Yamada, Mitsuhiko, Nagase, Hiroshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2014
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027615/
https://ncbi.nlm.nih.gov/pubmed/24900842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400491k
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