Metabolism of AM404 From Acetaminophen at Human Therapeutic Dosages in the Rat Brain

BACKGROUND: Acetaminophen, an analgesic and antipyretic drug, has been used clinically for more than a century. Previous studies showed that acetaminophen undergoes metabolic transformations to form an analgesic compound, N-(4-hydroxyphenyl) arachidonamide (AM404), in the rodent brain. However, thes...

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Detalhes bibliográficos
Publicado no:Anesth Pain Med
Main Authors: Muramatsu, Shun, Shiraishi, Seiji, Miyano, Kanako, Sudo, Yuka, Toda, Akiko, Mogi, Masayuki, Hara, Mayumi, Yokoyama, Akinobu, Kawasaki, Yoshihiko, Taniguchi, Mikio, Uezono, Yasuhito
Formato: Artigo
Idioma:Inglês
Publicado em: Kowsar 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834746/
https://ncbi.nlm.nih.gov/pubmed/27110534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5812/aapm.32873
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