Minibody-Indocyanine Green Based Activatable Optical Imaging Probes: The Role of Short Polyethylene Glycol Linkers

[Image: see text] Minibodies show rapider blood clearance than IgGs due to smaller size that improves target-to-background ratio (TBR) in in vivo imaging. Additionally, the ability to activate an optical probe after binding to the target greatly improves the TBR. An optical imaging probe based on a...

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Bibliographic Details
Main Authors: Watanabe, Rira, Sato, Kazuhide, Hanaoka, Hirofumi, Harada, Toshiko, Nakajima, Takahito, Kim, Insook, Paik, Chang H., Wu, Anna M., Choyke, Peter L., Kobayashi, Hisataka
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027604/
https://ncbi.nlm.nih.gov/pubmed/24900850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400533y
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