The effects of conjugate and light dose on photo-immunotherapy induced cytotoxicity

BACKGROUND: Photoimmunotherapy (PIT) is a highly cell-selective cancer therapy, which employs monoclonal antibodies conjugated to a potent photosensitizer (mAb-IR700). Once the conjugate has bound to the target cell, exposure to near infrared (NIR) light induces necrosis only in targeted cells with...

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Bibliographic Details
Main Authors: Nakajima, Takahito, Sato, Kazuhide, Hanaoka, Hirofumi, Watanabe, Rira, Harada, Toshiko, Choyke, Peter L, Kobayashi, Hisataka
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055275/
https://ncbi.nlm.nih.gov/pubmed/24885589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-389
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