Probing the Binding Site of Bile Acids in TGR5

[Image: see text] TGR5 is a G-protein-coupled receptor (GPCR) mediating cellular responses to bile acids (BAs). Although some efforts have been devoted to generate homology models of TGR5 and draw structure–activity relationships of BAs, none of these studies has hitherto described how BAs bind to T...

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Autors principals: Macchiarulo, Antonio, Gioiello, Antimo, Thomas, Charles, Pols, Thijs W. H., Nuti, Roberto, Ferrari, Cristina, Giacchè, Nicola, De Franco, Francesca, Pruzanski, Mark, Auwerx, Johan, Schoonjans, Kristina, Pellicciari, Roberto
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2013
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027510/
https://ncbi.nlm.nih.gov/pubmed/24900622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400247k
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