Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195

[Image: see text] To investigate the role played by the unique pre-DFG residue Val 195 of Cdc7 kinase on the potency of azaindole-chloropyridines (1), a series of novel analogues with various chloro replacements were synthesized and evaluated for their inhibitory activity against Cdc7. X-ray cocryst...

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Main Authors: Tong, Yunsong, Stewart, Kent D., Florjancic, Alan S., Harlan, John E., Merta, Philip J., Przytulinska, Magdalena, Soni, Nirupama, Swinger, Kerren K., Zhu, Haizhong, Johnson, Eric F., Shoemaker, Alexander R., Penning, Thomas D.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2013
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027468/
https://ncbi.nlm.nih.gov/pubmed/24900653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300348c
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