A semi-mechanistic integrated toxicokinetic–toxicodynamic (TK/TD) model for arsenic(III) in hepatocytes

BACKGROUND: A systems engineering approach is presented for describing the kinetics and dynamics that are elicited upon arsenic exposure of human hepatocytes. The mathematical model proposed here tracks the cellular reaction network of inorganic and organic arsenic compounds present in the hepatocyt...

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Bibliografiska uppgifter
Huvudupphovsmän: Stamatelos, Spyros K., Androulakis, Ioannis P., Kong, Ah-Ng Tony, Georgopoulos, Panos G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026948/
https://ncbi.nlm.nih.gov/pubmed/23069314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtbi.2012.09.019
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