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Using Network Biology to Bridge Pharmacokinetics and Pharmacodynamics in Oncology

If mathematical modeling is to be used effectively in cancer drug development, future models must take into account both the mechanistic details of cellular signal transduction networks and the pharmacokinetics (PK) of drugs used to inhibit their oncogenic activity. In this perspective, we present a...

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Detalhes bibliográficos
Main Authors: Kirouac, D C, Onsum, M D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026631/
https://ncbi.nlm.nih.gov/pubmed/24005988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2013.38
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