Metformin protects against systolic overload-induced heart failure independent of AMP-activated protein kinase α2

Activation of AMP-activated protein kinase (AMPK) α2 protects the heart against pressure overload-induced heart failure in mice. Although metformin is a known activator of AMPK, it is unclear whether its cardio-protection acts independently of an AMPKα2-dependent pathway. Because the role of AMPKα1...

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Huvudupphovsmän: Xu, Xin, Lu, Zhongbing, Fassett, John, Zhang, Ping, Hu, Xinli, Liu, Xiaoyu, Kwak, Dongmin, Li, Jingxin, Zhu, Guangshuo, Tao, Yi, Hou, Mingxiao, Wang, Huan, Guo, Haipeng, Viollet, Benoit, McFalls, Edward O., Bache, Robert J., Chen, Yingjie
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026291/
https://ncbi.nlm.nih.gov/pubmed/24420540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.113.02619
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