Double Stranded RNA–Dependent Protein Kinase Deficiency Protects the Heart from Systolic Overload-Induced Congestive Heart Failure

BACKGROUND: Double stranded RNA–dependent protein kinase (PKR) is a eukaryotic initiation factor 2α kinase that inhibits mRNA translation under stress conditions. PKR also mediates inflammatory and apoptotic signaling independent of translational regulation. Congestive heart failure (CHF) is associa...

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Main Authors: Wang, Huan, Xu, Xin, Fassett, John, Kwak, Dongmin, Liu, Xiaoyu, Hu, Xinli, Falls, Therasa J., Bell, John C., Li, Hongliang, Bitterman, Peter, Bache, Robert J., Chen, Yingjie
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972332/
https://ncbi.nlm.nih.gov/pubmed/24463368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.113.002209
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