Acute chest syndrome is associated with single nucleotide polymorphism-defined beta globin cluster haplotype in children with sickle cell anaemia

Genetic diversity at the human β-globin locus has been implicated as a modifier of sickle cell anaemia (SCA) severity. However, haplotypes defined by restriction fragment length polymorphism sites across the β-globin locus have not been consistently associated with clinical phenotypes. To define the...

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Hlavní autoři: Bean, Christopher J., Boulet, Sheree L., Yang, Genyan, Payne, Amanda B., Ghaji, Nafisa, Pyle, Meredith E., Hooper, W. Craig, Bhatnagar, Pallav, Keefer, Jeffrey, Barron-Casella, Emily A., Casella, James F., DeBaun, Michael R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026174/
https://ncbi.nlm.nih.gov/pubmed/23952145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.12507
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