Heme oxygenase-1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with sickle cell disease

Sickle cell disease is a common hemolytic disorder with a broad range of complications, including vaso-occlusive episodes, acute chest syndrome (ACS), pain, and stroke. Heme oxygenase-1 (gene HMOX1; protein HO-1) is the inducible, rate-limiting enzyme in the catabolism of heme and might attenuate th...

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Detalhes bibliográficos
Main Authors: Bean, Christopher J., Boulet, Sheree L., Ellingsen, Dorothy, Pyle, Meredith E., Barron-Casella, Emily A., Casella, James F., Payne, Amanda B., Driggers, Jennifer, Trau, Heidi A., Yang, Genyan, Jones, Kimberly, Ofori-Acquah, Solomon F., Hooper, W. Craig, DeBaun, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488892/
https://ncbi.nlm.nih.gov/pubmed/22966170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-361642
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