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SYK as a New Therapeutic Target in B-Cell Precursor Acute Lymphoblastic Leukemia

The identification of SYK as a master regulator of apoptosis controlling the activation of the PI3-K/AKT, NFκB, and STAT3 pathways—three major anti-apoptotic signaling pathways in B-lineage leukemia/lymphoma cells—prompts the hypothesis that rationally designed inhibitors targeting SYK may overcome...

詳細記述

保存先:
書誌詳細
主要な著者: Uckun, Fatih M., Qazi, Sanjive
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026065/
https://ncbi.nlm.nih.gov/pubmed/24851191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4236/jct.2014.51015
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