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SYK as a New Therapeutic Target in B-Cell Precursor Acute Lymphoblastic Leukemia
The identification of SYK as a master regulator of apoptosis controlling the activation of the PI3-K/AKT, NFκB, and STAT3 pathways—three major anti-apoptotic signaling pathways in B-lineage leukemia/lymphoma cells—prompts the hypothesis that rationally designed inhibitors targeting SYK may overcome...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
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2014
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4026065/ https://ncbi.nlm.nih.gov/pubmed/24851191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4236/jct.2014.51015 |
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