Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells

We show that expression of the microtubule depolymerizing kinesin KIF2C is induced by transformation of immortalized human bronchial epithelial cells by expression of K-Ras(G12V) and knockdown of p53. Further investigation demonstrates that this is due to the K-Ras/ERK1/2 MAPK pathway, as loss of p5...

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Main Authors: Zaganjor, Elma, Osborne, Jihan K., Weil, Lauren M., Diaz-Martinez, Laura A., Gonzales, Joshua X., Singel, Stina M., Larsen, Jill E., Girard, Luc, Minna, John D., Cobb, Melanie H.
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025984/
https://ncbi.nlm.nih.gov/pubmed/24240690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.486
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