Prodrugs of a CXC Chemokine-12 (CXCL12) Neutraligand Prevent Inflammatory Reactions in an Asthma Model in Vivo

[Image: see text] Chalcone 4 (compound 1) is a small molecule that neutralizes the CXC chemokine CXCL12 and prevents it from acting on the CXCR4 and CXCR7 receptors. To overcome its poor solubility in aqueous buffers, we designed highly soluble analogues of compound 1, phosphate, l-seryl, and sulfat...

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Autors principals: Gasparik, Vincent, Daubeuf, François, Hachet-Haas, Muriel, Rohmer, François, Gizzi, Patrick, Haiech, Jacques, Galzi, Jean-Luc, Hibert, Marcel, Bonnet, Dominique, Frossard, Nelly
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2011
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025865/
https://ncbi.nlm.nih.gov/pubmed/24900366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200017d
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