Prodrugs of a CXC Chemokine-12 (CXCL12) Neutraligand Prevent Inflammatory Reactions in an Asthma Model in Vivo

[Image: see text] Chalcone 4 (compound 1) is a small molecule that neutralizes the CXC chemokine CXCL12 and prevents it from acting on the CXCR4 and CXCR7 receptors. To overcome its poor solubility in aqueous buffers, we designed highly soluble analogues of compound 1, phosphate, l-seryl, and sulfat...

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Detalhes bibliográficos
Main Authors: Gasparik, Vincent, Daubeuf, François, Hachet-Haas, Muriel, Rohmer, François, Gizzi, Patrick, Haiech, Jacques, Galzi, Jean-Luc, Hibert, Marcel, Bonnet, Dominique, Frossard, Nelly
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025865/
https://ncbi.nlm.nih.gov/pubmed/24900366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200017d
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