A Divergent SAR Study Allows Optimization of a Potent 5-HT(2c) Inhibitor to a Promising Antimalarial Scaffold

[Image: see text] From the 13 533 chemical structures published by GlaxoSmithKline in 2010, we identified 47 quality starting points for lead optimization. One of the most promising hits was the TCMDC-139046, a molecule presenting an indoline core, which is well-known for its anxiolytic properties b...

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Main Authors: Calderón, Félix, Vidal-Mas, Jaume, Burrows, Jeremy, de la Rosa, Juan Carlos, Jiménez-Díaz, María Belén, Mulet, Teresa, Prats, Sara, Solana, Jorge, Witty, Michael, Gamo, Francisco Javier, Fernández, Esther
פורמט: Artigo
שפה:Inglês
יצא לאור: American Chemical Society 2012
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025835/
https://ncbi.nlm.nih.gov/pubmed/24900481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300008j
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