Dual-Target Virtual Screening by Pharmacophore Elucidation and Molecular Shape Filtering

[Image: see text] Dual-target inhibitors gained increased attention in the past years. A novel in silico approach was employed for the discovery of dual 5-lipoxygenase/soluble epoxide hydrolase inhibitors. The ligand-based approach uses excessive pharmacophore elucidation and pharmacophore alignment...

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Hlavní autoři: Moser, Daniel, Wisniewska, Joanna M., Hahn, Steffen, Achenbach, Janosch, Buscató, Estel·la, Klingler, Franca-Maria, Hofmann, Bettina, Steinhilber, Dieter, Proschak, Ewgenij
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2012
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025812/
https://ncbi.nlm.nih.gov/pubmed/24900445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200286e
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